By Jay D. Humphrey, Sherry L. O'Rourke
This booklet covers the basics of biomechanics. themes contain bio solids, biofluids, tension, stability and equilibrium. scholars are inspired to contextualize ideas and workouts inside a “big photograph” of biomechanics. this is often an incredible ebook for undergraduate scholars with pursuits in biomedical engineering.
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Extra info for An Introduction to Biomechanics: Solids and Fluids, Analysis and Design
In other words, the continuum assumption (or hypothesis) tends to be reasonable when δ/λ ( 1, where δ is a characteristic length scale of the microstructure and λ is a characteristic length scale of the physical problem of interest. For the rocket, δ may be the distance between the individual molecules of the air and λ the diameter of 10 1. Introduction the rocket. In this case, the ratio of δ/λ is much less than 1 near the ground but perhaps on the order of 1 in the upper atmosphere. With regard to biomechanics, consider the following.
Integrins are found in large numbers, but their binding to a particular ligand tends to be weak. This would be advantageous in cell migration, for example, wherein local adhesion would be short-lived. Cells can regulate the activity of their integrins, and, conversely, gene expression can be mediated by the extracellular matrix via the integrins. Finally, note that some of the embedded membrane proteins are decorated with carbohydrates; this glycocalyx, or “sugar coat,” appears to protect the cell from mechanical and chemical damage and may participate in certain transient adhesion processes.
As noted earlier, phagocytosis can be a highly selective mechanism of degradation. It also appears that much of the synthesized collagen is degraded prior to its incorporation into the ECM (McAnulty and Laurent 1987). , a cellular quality control). In response to disease or injury, however, the rates and control of the continual degradation and synthesis can change dramatically, as needed. Wound healing in skin is a prime example of an accelerated turnover of collagen, which in this case may result in a collagenous scar.
An Introduction to Biomechanics: Solids and Fluids, Analysis and Design by Jay D. Humphrey, Sherry L. O'Rourke